The development of human beings’ intersubjective nature starts immediately after birth and probably represents the foundational principle of our meaning-making ability. Since the very beginning of our life, relationality plays a key role in our existence: infants’ ability to imitate facial expressions not only guarantees their survival but also allows them to interact with their mothers in an attuned way, thus creating increasingly complex relational exchanges, which are fundamental to their psychobiological development. The discovery of mirror neurons has provided a neurophysiological basis for the Still Face paradigm and made a substantial contribution to scientific research in this field. How can Psychotherapy build on this valuable knowledge in order to promote individual wellbeing? The Congress “Still Face and Mirror Neurons – the Neuroscience of Psychotherapy” will give some of the most eminent experts in this field the opportunity to answer this question. A number of internationally well-known Speakers will illustrate the most recent studies on the role of emotional/relational attunement and the individual’s relationship with the Self, by exploring both the research implications and the therapeutic applications in this field. They will emphasize how intersubjectivity is not strictly related to the relationship with the Other, but also involves the relationship with the Self, which is one of the main goals of the psychotherapeutic change process. In addition, different therapeutic approaches and a series of hypotheses on mind functioning – that Neuroscience can support and validate – will also be discussed. Besides this, Speakers will focus on the role of self-recognition in the mirror, as well as on the shame and self-loathing that traumatized individuals typically experience, in order to deeply explore the relational dimension of the Self within the most advanced therapeutic frameworks.